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Aubrey sinclai

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I guess that's what you have to expect when you are one of the instigator of a paradigm shift. Degrey , I believe, got his Phd "By publication" which is something that has been done for quite some time at cambridge and some english universities.

His work was then examined as any other dissertation would be by a committee, and was awarded his Phd. He just did the work "by himself" if you will.

About a year or two ago Aubrey de Grey made a legit math breakthrough. So Aubrey does math for fun and exhibited some seriously legit math problem solving ability.

The dude is super smart. Sirt1 helps induce autophagy which breaks down "garbage". Has Sinclair said that aspect of Sirt1 activation is immaterial?

I am only 50 pages into his new book and honestly there's a lot to take in I don't know every single detail about every single sirtuin you know lol.

That's why I'm here asking. Someone asked him a similar question in regards to how his theory reconciles with the "9 hallmarks of aging". It's great to say that these hallmarks cause aging, but it doesn't explain why they happen.

Is there an upstream cause of all of those? Or are we building 7 dams on 7 tributaries? The information theory proposes and can explain how epigentic aging, the loss of gene expression as we get older can explain all of those hallmarks as well.

In fact, if we look at those mice, even though we've just disrupted the epigenome, they have all of those hallmarks. From mitochondrial dysfunction to scenecent cells.

Scenecent cells being the ultimate expression of a "scratched CD". I'm excited about this theory because it can explain the last years of observations.

All theories can succumb to a paradigm shift and I'm not saying this is the "be-all end-all" but I think it's a great way to think about aging and brings up a lot of testable hypotheses such as the mice I showed you.

What are the chances we'd get an old mouse when you cut the genome like that? One in a thousand and it works, so we continue to test this theory but so far it seems to explain, in my view, all the observations over the past years.

Garbage inside of cells is in the "loss of proteostasis" category of the hallmarks, if that's what you are looking for. De grey has no lab, no grad students, and his only peer-reviewed publications in the field are literature reviews reflecting his beliefs.

He's an advocate for engineering approaches to regenerative medicine, rather than a scientist. Most boardmembers of disease research advocacy groups are also not scientists.

Yet they still fund science. Micalizio, A. Bains for helpful discussions. It's pretty insulting to depict him as a mere showman after all the scientific contributions he's given the world.

I don't consider him a showman. I consider him a research advocate. Even an expert. But not an experimenter.

Having spent a stretch as a grad student, I find most laypersons underestimate the demands placed on scientists in academia. For every successful series of experiments that get published, there are quite a few that go nowhere.

Nights taken up applying for grants. For many, teaching requirements as well. Until the upper echelons of administration or a successful biotech IPO, working for a pittance compared to what the same skillset might command in clinical medicine or the wider industry.

Every theoretician in every scientific discipline would have a bone to pick with you. Hell, most PIs and lab leaders aren't scientists by this classification.

Science is the intellectual activity, not the bench work. Certainly Aubrey is a scientist. He more or less said on his last Joe Rogan appearance that we should "set that idea a side for now if not forever".

What exactly in Sinclair suggesting be done for the large range of biological structures which are not turned over to any appreciable extent by the body then?

Isnt it interesting that if you take a neuron from a mice and transplant it into a species that lives twice as long the neuron lives twice as long, the researchers commenting the cell is potentially immortal and would live just as much as its host organism.

They're both great self-promoters, but neither of them are the people who will be making the actual advances. Come on guys let's get this question answered once and for all, David Sinclair obviously doesn't think anything like garbage building up inside of cells has anything to do with aging so why is Aubrey de grey proposing the hypothesis?

I'm starting to question whether Aubrey is a quack or not? So until David Sinclair came along Aubrey de grey was the most visible figure in aging research, I mean I believe I first read about Aubrey de grey and his theory of humans living to be a thousand years old back in in some magazine at the gym I was working out at when I was 15 years old, so he's been the most prominent voice on aging science for a long time.

So of course I'm sure David Sinclair has been asked about what his thoughts are on Aubrey de grey? Because David is stealing the spotlight from Aubrey and so I am very curious who's right and who's wrong?

I honestly am not too familiar with Aubrey de Grey but I have been following Sinclair for a long time. I think you might be viewing scientific research in a bit of a weird way.

Like there are general ideas and research tends to just hyper focus on certain aspects. Sinclair has done a lot of work spotting the genetic machinery involved with autophagy.

He has been able to find the genetic trigger for autophagy the Sirtuin family of genes and then test thousands of different exogenous compounds to find its agonist.

First off if you haven't read his new book you need to I am only 50 pages in but damn he has me convinced that he's a true pioneer and a genius, he has possibly figured out the unified theory of aging just go read the book.

In my opinion the reason that Sinclair is taking the spotlight is because his message resonates more with layperson.

Eat this, eat less, exercise, are all things we can relate to in every day experiences. However, protein-digesting bacteria injected in a human body might not receive similair enthusiasm from this group.

Basically in my view the lack of imagination of many enthusiasts makes sure that they are biased towards solutions involving means that we can relate to in everyday life.

Hence Sinclair is more populair. You haven't read his new book? This page will put a light upon the Aubrey Sinclair bio, wiki, age, birthday, family details, affairs, boyfriend, controversies, caste, height, weight, rumors, lesser-known facts, and more.

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